Tetrahydrofuran → HCID 131731998, compound

Participants

Reaction Steps

To a stirred solution of (R)-quinuclidin-3-yl(3-(8-(1,3-dioxolan-2-yl)octyloxy)phenyl)(phenyl)methylcarbamate (0.66 g, 1.23 mmol) in THF (10 mL), 2M hydrochloric acid was added (20 mL). The reaction mixture was stirred at RT for 3 hours. To the reaction mixture was added 10% aqueous potassium carbonate, and the mixture extracted with DCM (×3). The combined organic extracts were washed poured through a hydrophobic cartridge, and concentrated under reduced pressure to afford the title compound (0.64 g, quantitative yield). The material was used directly in the next step with no further purification.

Provenance & Evidence