反应详情

温度

100 °C

To a solution of (3-((1,3-dioxolan-2-yl)methyl)phenyl)methanol (prepared as in Example 22, Step 1 with 3-((1,3-dioxolan-2-yl)methyl)benzoic acid replacing 4-((1,3-dioxolan-2-yl)methyl)benzoic acid; 0.47 g, 2.42 mmol) in 1,4-dioxane (8 mL), manganese (IV) oxide (2.35 g) was added. The resulting suspension was heated at 100° C. for 16 hours. The reaction mixture was allowed to cool, and the suspension was filtered through a pad of celite. The celite pad was washed with ethyl acetate and the filtrate evaporated at reduced pressure to afford the title compound (0.352 g, 76%).

1. temperatureto cool
2. filtrationthe suspension was filtered through a pad of celite
3. washThe celite pad was washed with ethyl acetate
4. customthe filtrate evaporated at reduced pressure