Sodium borohydride → HCID 71093329, compound

Participants

Reaction Steps

To an ice-cooled solution of 3-(3-(1,3-dioxolan-2-yl)propoxy)benzaldehyde (prepared as in Example 10; Step 1) (3.08 g, 13.1 mmol) in ethanol (66 mL), was added sodium borohydride (1.98 g, 52.4 mmol). The reaction mixture was allowed to warm to ambient temperature and stirred at ambient temperature for 16 hours. The reaction mixture was carefully quenched with saturated aqueous ammonium chloride and extracted twice with DCM. The combined organic phases were poured through a hydrophobic column, and the solvent was evaporated at reduced pressure to afford the title compound as a colourless oil (2.96 g, 95%).

Provenance & Evidence