Formamide → HCID 86676910, compound

HRID 332689Notes

Reaction equation

HRID 332689 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][CH:15]=1)[C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)=O.[CH:16]([NH2:18])=[O:17]>O>[OH:1][C:2]1[CH:3]=[C:4]([CH:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[NH:18][CH:16]=[O:17])[CH:13]=[CH:14][CH:15]=1

Participants

4

Reactant 2

HCID 713FormamideHCID 830503-Hydroxybenzophenone

Product 1

HCID 86676910HCID 86676910, compoundYield 4,525.6%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
50 °C

Procedure

3-Hydroxybenzophenone (25 g, 126.1 mmol) in formamide (130 mL, 3.3 mmol) was heated to 180° C. for 18 hours. The reaction was allowed to cool slightly then poured into ice-cooled water and stirred for 30 minutes, filtered, and washed with water. The solid was stirred in water (60 mL) and ethanol (60 mL) and heated to 50° C. for 1 hour, then allowed to cool. The solid was filtered and washed with water to give the title compound (33.94 g, 118%).

Workup

  1. temperatureto cool slightly
  2. additionthen poured into ice-
  3. filtrationfiltered
  4. washwashed with water
  5. stirringThe solid was stirred in water (60 mL)
  6. temperatureto cool
  7. filtrationThe solid was filtered
  8. washwashed with water

Sources & evidence

ORD record
ord-0a855ebc4abe480d93cfa0e6a76b7ea1
Source dataset
uspto-grants-2014_11
Patent number
US08877774B2

Reaction notes

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