Hydrochloric Acid → HCID 71093085, compound

Participants

Reaction Steps

Methanol (125 mL), was cooled to 0° C., and acetyl chloride (17.8 mL) added dropwise to give a 2M solution of methanolic hydrogen chloride. N-((3-hydroxyphenyl)-(phenyl)methyl)formamide was stirred at 40° C. for 1.5 hours with the 2M methanolic hydrogen chloride. The solvent was removed under reduced pressure and the residue re-dissolved in methanol and the solvent removed under reduced pressure. This process was repeated three times to give the title compound (29.09 g, 97.9%).

Provenance & Evidence