HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (S)-3-(1,3-Dioxolan-2-yl)propyl 2-amino-3-phenylpropanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]- | HCID 77857 | — |
| Reactant | 2-(3-Chloropropyl)-1,3-dioxolane | HCID 552072 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (S)-3-(1,3-Dioxolan-2-yl)propyl 2-amino-3-phenylpropanoate | HCID 71113124 | — |
Reaction Steps
The title compound was prepared in two steps. Boc-Phe-OH was reacted with 2-(3-chloropropyl)-1,3-dioxolane according to Example 10 Step 1, and the subsequent product reacted with hydrogen chloride in dioxan according to Example 79 Step 5.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08877774B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-981eb4ca7d664fe68fd01923aa795e02 |
| Source note | uspto-grants-2014_11 |