Hydrochloric Acid → HCID 86676914, compound

Participants

Reaction Steps

To a solution of tert-butyl((3-((5-(1,3-dioxolan-2-yl)pentyl)oxy)phenyl)(phenyl)-methyl)carbamate (0.483 g, 1.10 mmol) in methanol (4 mL), was added hydrogen chloride in dioxan (4 M, 4 mL, 16 mmol). The reaction was stirred at ambient temperature for 7 hours. The solvent was evaporated at reduced pressure, and the residue loaded onto an SCX-2 cartridge. The cartridge was eluted with methanol (eight column volumes) followed by ammonia/methanol. Fractions containing the product were combined and evaporated at reduced pressure to afford the title compound as a colourless oil (0.322 g, 85%).

Provenance & Evidence