HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-O-benzoyl-1,3-propanediol → 3-(3-(((tert-Butoxycarbonyl)amino)(phenyl)methyl)phenoxy)propyl benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-O-benzoyl-1,3-propanediol | HCID 81378 | — |
| Reactant | 3-Hydroxybenzophenone | HCID 83050 | — |
| Reactant | tert-Butyl ((3-hydroxyphenyl)(phenyl)methyl)carbamate | HCID 71113120 | — |
| Reactant | (4-((1,3-Dioxolan-2-yl)methyl)phenyl)methanol | HCID 86676898 | — |
| Product | 3-(3-(((tert-Butoxycarbonyl)amino)(phenyl)methyl)phenoxy)propyl benzoate | HCID 71093231 | — |
Reaction Steps
The title compound was prepared as described in Example 22 Step 3 with 3-hydroxypropyl benzoate (prepared as outlined in Organic & Biomolecular Chemistry, 8(24), 5505-5510; 2010, which is incorporated herein by reference in its entirety) and tert-butyl((3-hydroxyphenyl)(phenyl)methyl)carbamate (derived from the second eluting isomer Chiral Example 1 Step 4) replacing (4-((1,3-dioxolan-2-yl)methyl)phenyl)methanol and 3-hydroxybenzophenone respectively.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08877774B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-9bfae8273bfd4984901b5a21f3afc130 |
| Source note | uspto-grants-2014_11 |