反应详情

温度

80 °C

To a stirred solution of benzyl 4-((3-(((tert-butoxycarbonyl)amino)(phenyl)-methyl)phenoxy)methyl)piperidine-1-carboxylate (1.12 g, 2.11 mmol) in ethanol (10 mL), was added 10% palladium on charcoal (0.22 g) and 1-methyl1,4-cyclohexadiene (1.18 mL, 10.55 mmol). The reaction mixture was heated to 80° C. for 7 hours. The reaction mixture was filtered through a pad of celite, and the filter-pad washed with further ethanol. The filtrate was evaporated at reduced pressure to afford the title compound (0.716 g, 85%).

1. filtrationThe reaction mixture was filtered through a pad of celite
2. washthe filter-pad washed with further ethanol
3. customThe filtrate was evaporated at reduced pressure