Propargyl alcohol → HCID 178469099, compound

HRID 33278Notes

Reaction equation

HRID 33278 reaction equation
[CH2:1]([OH:4])[C:2]#[CH:3].[N+:5](=[CH:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])=[N-:6]>ClC(Cl)Cl>[CH2:11]([O:10][C:8]([C:7]1[NH:5][N:6]=[C:2]([CH2:1][OH:4])[CH:3]=1)=[O:9])[CH3:12]

Participants

4

Reactant 2

HCID 7859Propargyl alcoholHCID 12192Ethyl diazoacetate

Product 1

HCID 178469099HCID 178469099, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A solution of 2 g Prop-2-yn-1-ol and 3 g Ethyl diazoacetate in 16 ml trichloromethane was stirred at 70° C. for 24 h. Then the solvent was removed under reduced pressure and the residue was purified on silica gel eluting with a gradient n-heptane/ethyl acetate 1:1->1:2. The fractions containing the product were collected and evaporated under reduced pressure. Yield: 1.9 g.

Workup

  1. customThen the solvent was removed under reduced pressure
  2. customthe residue was purified on silica gel eluting with a gradient n-heptane/ethyl acetate 1:1->1:2
  3. additionThe fractions containing the product
  4. customwere collected
  5. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-06b9d77feabc461d851af6f9f260d539
Source dataset
uspto-grants-2008_09
Patent number
US07429581B2

Reaction notes

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