Potassium Carbonate → HCID 86685606, 화합물

HRID 332814노트

반응식

HRID 332814 반응식
[C:1]([C:3]1[N:4]=[CH:5][C:6]([NH:17][C@H:18]([CH2:22][CH:23]([CH3:25])[CH3:24])[C:19]([NH2:21])=[O:20])=[N:7][C:8]=1[NH:9][C:10]1[CH:11]=[C:12]([CH3:16])[CH:13]=[CH:14][CH:15]=1)#[N:2].C([O-])([O-])=[O:27].[K+].[K+]>CO.OO>[NH2:21][C:19](=[O:20])[C@H:18]([NH:17][C:6]1[N:7]=[C:8]([NH:9][C:10]2[CH:11]=[C:12]([CH3:16])[CH:13]=[CH:14][CH:15]=2)[C:3]([C:1]([NH2:2])=[O:27])=[N:4][CH:5]=1)[CH2:22][CH:23]([CH3:25])[CH3:24]

참가 물질

5

반응물 2

HCID 11430Potassium CarbonateHCID 86685605HCID 86685605, 화합물

생성물 1

HCID 86685606HCID 86685606, 화합물

시약·촉매·용매 2

HCID 784Hydrogen Peroxide촉매HCID 887Methanol용매

실험 절차

To a mixture of (R)-2-(5-cyano-6-(m-tolylamino)pyrazin-2-ylamino)-4-methylpentanamide in methanol (1 ml) was added K2CO3 (excess)) and H2O2 (50%, a few drops). After completion, it was concentrated and purified by preparative HPLC to give (R)-5-(1-amino-4-methyl-1-oxopentan-2-ylamino)-3-(m-tolylamino)pyrazine-2-carboxamide (6 mg). MS found for C18H24N6O2 as (M+H)+ 357.3, UV: λ=253.4, 304.5.

후처리

  1. concentrationAfter completion, it was concentrated
  2. custompurified by preparative HPLC

출처 및 근거

ORD 기록
ord-34b18a1310554bc486f2186241029c27
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08877760B2

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