反应详情

温度

-78 °C

The solution of 2,6-dichloro-5-methoxy-4-vinyl pyrimidine (50 g, 0.24 mol) in dichloromethane:methanol (4:1, 2 L), prepared by Example 1, was cooled to −78° C. Ozone gas was bubbled through for 5 h. The reaction was quenched with dimethyl sulfide (50 mL). The mixture was slowly warmed to room temperature and concentrated under reduced pressure at 40° C. to provide a crude material comprising the title compound (50.5 g, 100% yield); HPLC (85% acetonitrile buffered with 0.1% v/v acetic acid. The title compound was not isolated from the crude material.

1. customOzone gas was bubbled through for 5 h
2. customThe reaction was quenched with dimethyl sulfide (50 mL)
3. temperatureThe mixture was slowly warmed to room temperature
4. concentrationconcentrated under reduced pressure at 40° C.
5. customto provide a crude material