反应详情

4-Chloroquinoline (0.82 g, 5 mmol), valinamide (0.64 g, 5.5 mmol) and diisopropylamine (1.9 ml, 11 mmol) were mixed with 1-methoxy-2-propanol (8 ml) and heated with stirring at reflux for 48 hours. The solvent was removed under reduced pressure, the residue was partitioned between water and ethyl acetate, the phases were separated, the aqueous phase was washed 3 times with ethyl acetate and basified with 50% NaOH. A precipitate formed that was filtered off and dried in air to give 0.2 g of a solid (0.78 mmol, 14%). MS (APCI) M/z=243.6 [M+H]+.

1. temperatureheated
2. temperatureat reflux for 48 hours
3. customThe solvent was removed under reduced pressure
4. customthe residue was partitioned between water and ethyl acetate
5. customthe phases were separated
6. washthe aqueous phase was washed 3 times with ethyl acetate
7. customA precipitate formed
8. filtrationthat was filtered off
9. customdried in air