Ethylenediamine → N-(5-Ethyl-6-methyl-pyrimidin-4-yl)ethane-1,2-diamine hydrochloride

Participants

Role	Name	HCID	Charge
Reactant	Ethylenediamine	HCID 3301	—
Reactant	4-Chloro-5-ethyl-6-methylpyrimidine	HCID 61252025	—
Product	N-(5-Ethyl-6-methyl-pyrimidin-4-yl)ethane-1,2-diamine hydrochloride	HCID 66834918	144.8%

Reaction Conditions

Temperature	150 °C

Reaction Steps

4-Chloro-5-ethyl-6-methylpyrimidin (570 mg, 4 mmol) was mixed with 1,2-diaminoethane (2 ml, 30 mmol) and stirred at 150° C. in a closed vessel under microwave heating. The mixture was evaporated to dryness under reduced pressure to yield 1.255 g of a solid. MS (APCI) m/z=181.1 [M+H]+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08877934B2
Source dataset	uspto-grants-2014_11
ORD ID	ord-a2eefbeaf0184e2bbe6b4eb241b7ac72
Source note	uspto-grants-2014_11