HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylene Glycol → 4-Chloro-2-(2-methyl-1,3-dioxolan-2-yl)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylene Glycol | HCID 174 | — |
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | 1-(4-Chloro-pyridin-2-yl)-ethanone | HCID 13011986 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 4-Chloro-2-(2-methyl-1,3-dioxolan-2-yl)pyridine | HCID 66835514 | 93% |
Reaction Steps
1-(4-Chloro-2-pyridyl)ethanone (440 mg, 2.83 mmol) and ethyleneglycol (480 mg, 3 mmol) were mixed with toluene (10 ml), a catalytic amount of p-toluenesulfonic acid was added and the mixture was heated at reflux overnight. The mixture was evaporated to dryness to yield 523 mg of a solid (2.6 mmol, 93%). MS (APCI) m/z=200.0 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08877934B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-faee9a2986ae4126a0a32cb0eb91dd6a |
| Source note | uspto-grants-2014_11 |