反应详情

Ethyl (E)-4,4,5,5-tetrafluoropent-2-enoate (15.9 g, 0.08 mol) was dissolved in ethanol (30 ml), 4M NaOH was added (15 ml) and the mixture was stirred at room temperature overnight. The mixture was diluted with water, washed with ethylacetate, acidified with 1M HCl and extracted with ethyl acetate. The organic extract was dried over magnesium sulfate, the solvent was removed under reduced pressure. 12.8 g of a colourless oil was obtained (0.074 mmol, 93%). MS (ESI, negative detection) m/z=170.9 [M−1]−.

1. washwashed with ethylacetate
2. extractionextracted with ethyl acetate
3. extractionThe organic extract
4. dry with materialwas dried over magnesium sulfate
5. customthe solvent was removed under reduced pressure