Di(succinimido) carbonate → HCID 131730601, compound

HRID 333108Notes

Reaction equation

HRID 333108 reaction equation
C1C(=O)N(O[C:9]([O:11][N:12]2[C:17](=[O:18])[CH2:16][CH2:15][C:13]2=[O:14])=[O:10])C(=O)C1.[NH2:19][C:20]1[CH:25]=[CH:24][C:23]([NH:26][C:27]([NH:29][CH2:30][CH2:31][NH:32][C:33]([O:35][C:36]([CH3:39])([CH3:38])[CH3:37])=[O:34])=[O:28])=[CH:22][CH:21]=1>CC#N>[C:36]([O:35][C:33]([NH:32][CH2:31][CH2:30][NH:29][C:27]([NH:26][C:23]1[CH:24]=[CH:25][C:20]([NH:19][C:9]([O:11][N:12]2[C:13](=[O:14])[CH2:15][CH2:16][C:17]2=[O:18])=[O:10])=[CH:21][CH:22]=1)=[O:28])=[O:34])([CH3:39])([CH3:37])[CH3:38]

Participants

4

Reactant 2

HCID 676246Di(succinimido) carbonateHCID 671212751,1-Dimethylethyl N-[2-[[[(4-aminophenyl)amino]carbonyl]amino]ethyl]carbamate

Product 1

HCID 131730601HCID 131730601, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

N,N′-Disuccinimidylcarbonate (5.49 g, 21.44 mmol, 1.1 eq) is added at room temperature to a stirred solution of N-(4-aminophenyl)({2-[(tert-butoxy)carbonyl-amino]ethyl}amino)carboxamide (6.75 g, 19.49 mmol, 1.0 eq) in CH3CN (350 mL).

Sources & evidence

ORD record
ord-060013d8577b46748fd11e28b47b7094
Source dataset
uspto-grants-2014_11
Patent number
US08877961B2

Reaction notes

Loading…