HRID333145

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2734361

Indole-5-boronic acid

C8H8BNO2

HCID2734390

3,4,5-Trimethoxyphenylboronic acid

C9H13BO5

HCID2756555

5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine

C11H17BN2O2

结构：Cc1ccc(S(=O)(=O)n2cc(I)c3cc(Br)cnc32)cc1

HCID49759066

5-Bromo-3-iodo-1-(4-methylbenzene-1-sulfonyl)-1H-pyrrolo[2,3-b]pyridine

C14H10BrIN2O2S

结构：Cc1ccc(S(=O)(=O)n2cc(-c3ccc4[nH]ccc4c3)c3cc(Br)cnc32)cc1

HCID66779176

未命名化合物

PRODUCTS

生成物

结构：NC(=O)c1ccc(-c2c[nH]c3ncc(-c4ccc(N)nc4)cc23)cc1

HCID46234352

未命名化合物

PROCEDURE

实验过程

Compound AE was prepared by a method analogous to that described in Example 1 by substituting 4-carbamoylphenylboronic acid for 1H-indol-5-ylboronic acid in the reaction with Intermediate A and 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine for 3,4,5-trimethoxyphenylboronic acid in the reaction with Intermediate B. HPLC retention time: 1.13 minutes. MS ESI (m/z): 330.4 (M+H)+, calc. 329.

WORKUP

后处理

customCompound AE was prepared by a method analogous to