Methylamine → HCID 66819845、化合物

関与物質

反応手順

To a stirred suspension of 2-chloro-N-(6-oxo-5,6-dihydro-phenanthridin-2-yl)-acetamide (XVIII, Lg=Cl, 150 mg, 0.52 mmol) in N,N-dimethylformamide (1.4 mL), a 33% solution of methylamine in ethanol was added (9 mL, 72 mM). The reaction mixture was stirred at room temperature for 3 hours. The ethanol was then evaporated under reduced pressure and the mixture was diluted with diethyl ether and filtered. A light-yellow solid was then collected, washed with diethyl ether then with cold water and dried. The title compound was obtained in moderate yield (100 mg, 68%).

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