反应详情

To a solution of 6-fluoro-naphthalene-2-carboxylic acid (3.0 g, 15.8 mmol) was added BH3.THF (31.6 mL, 31.6 mmol). The reaction mixture was stirred overnight before being concentrated. To the residue was added diethyl ether (100 mL) and NaOH solution (10 mL). The organic layer was separated, dried and concentrated. The resultant residue was purified by silica gel column chromatography (ethyl acetate/hexane 1:7) to afford (6-fluoro-naphthalen-2-yl)-methanol (2.28 g, 82%).

1. concentrationbefore being concentrated
2. additionTo the residue was added diethyl ether (100 mL) and NaOH solution (10 mL)
3. customThe organic layer was separated
4. customdried
5. concentrationconcentrated
6. customThe resultant residue was purified by silica gel column chromatography (ethyl acetate/hexane 1:7)