反应详情

To a solution of (6-fluoro-naphthalen-2-yl)-methanol (2.0 g, 11.3 mmol) in CH2Cl2 (30 mL) was added PBr3 (1.0 M in CH2Cl2, 22.6 mmol). The reaction mixture was stirred for 3 h at room temperature before being quenched by NH4Cl (30 mL). The organic layer was separated, dried and concentrated. The resultant residue was purified by silica gel column chromatography (ethyl acetate/hexane=1:10) to afford 2-bromomethyl-6-fluoro-naphthalene (2.23 g, 74%).

1. custombefore being quenched by NH4Cl (30 mL)
2. customThe organic layer was separated
3. customdried
4. concentrationconcentrated
5. customThe resultant residue was purified by silica gel column chromatography (ethyl acetate/hexane=1:10)