Dimethylamine → HCID 53317145, compound

HRID 333249Notes

Reaction equation

HRID 333249 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2([C:14](O)=O)[CH2:13][CH2:12][CH2:11][CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8].[CH3:17][NH:18][CH3:19]>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2([CH2:14][N:18]([CH3:19])[CH3:17])[CH2:13][CH2:12][CH2:11][CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

3

Reactant 2

HCID 674DimethylamineHCID 886189HCID 886189, compound

Product 1

HCID 53317145HCID 53317145, compoundYield 87%

Procedure

The title compound was synthesized from 1-(3,4-dichlorophenyl)-cyclopentanecarboxylic acid and dimethyl amine using General Procedure G1, followed by General Procedure E in 87% yield. LCMS Rt=8.69 min, m/z=272 (M+1). 1H NMR (CDCl3, δ): 7.40 (d, J=2.2 Hz, 1H), 7.30 (d, J=8.4 Hz, 1H), 7.10 (dd, J=2.1, 8.4 Hz, 1H), 2.43 (s, 2H), 20.1 (s, 6H), 2.0-1.6 (m, 8H). 13C NMR (CDCl3, δ, mult): 149.2(0), 129.5(0), 129.2(1), 126.7(1), 131.6(1), 69.3(2), 52.1(0), 48.0(3), 36.0(2), 23.2(2),

Sources & evidence

ORD record
ord-5115f92a3b924227a81b299acdca33ab
Source dataset
uspto-grants-2014_11
Patent number
US08877975B2

Reaction notes

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