Ammonia → 771583-24-5

HRID 333251Notes

Reaction equation

HRID 333251 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:14](O)=O)[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[NH3:17]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([CH2:14][NH2:17])[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 7361361-(4-Fluorophenyl)cyclohexane-1-carboxylic acid

Product 1

HCID 20110059771583-24-5Yield 99%

Procedure

The title compound was synthesized from 1-(4-fluorophenyl)-cyclohexane-carboxylic acid and ammonia using General Procedure G, followed by General Procedure E in 99% yield as a clear oil. LCMS Rt=6.76 min, m/z=208 (M+1). 1H NMR (CDCl3, δ): 7.24 (ddd, J=3.2, 5.4, 12.2 Hz, 2H), 7.00 (t, J=8.8 Hz, 2H), 2.67 (s, 2H), 2.1 (m, 2H), 1.6-1.2 (m, 8H), 0.79(bs, 2H). 13C NMR (CDCl3, δ, mult): 162.1(0), 159.7(0), 140.3(0), 128.7(1), 128.6(1), 115.1(1), 114.9(1), 54.8(2), 43.2(0), 33.8(2), 26.6(2), 22.1(2).

Sources & evidence

ORD record
ord-822af7b6dd6d4884b50449f697ad6242
Source dataset
uspto-grants-2014_11
Patent number
US08877975B2

Reaction notes

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