Dimethylamine → HCID 53317168, compound

HRID 333256Notes

Reaction equation

HRID 333256 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2([CH:15]=O)[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)[CH:5]=[CH:6][C:7]=1[F:8].[CH3:17][NH:18][CH3:19].ClC1C=C(C2(CNC)CCCCC2)C=CC=1F>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2([CH2:15][N:18]([CH3:19])[CH3:17])[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)[CH:5]=[CH:6][C:7]=1[F:8]

Participants

4

Reactant 3

HCID 674DimethylamineHCID 53325042HCID 53325042, compoundHCID 86614757HCID 86614757, compound

Product 1

HCID 53317168HCID 53317168, compoundYield 88%

Procedure

The title compound was synthesized from 1-(3-chloro-4-fluorophenyl)cyclohexanecarbaldehyde and dimethyl amine using General Procedure H1 and was obtained in 88% yield as an oily solid. The title compound was also synthesized from 1-(1-(3-chloro-4-fluorophenyl)-cyclohexyl)-N-methylmethanamine according to General Procedure C.

Workup

  1. customwas obtained in 88% yield as an oily solid

Sources & evidence

ORD record
ord-d5ac7acb83714a80960845127fe6125c
Source dataset
uspto-grants-2014_11
Patent number
US08877975B2

Reaction notes

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