反应详情

温度

65 °C

A mixture of 1-(3,4-dichlorophenyl)cyclopent-3-enecarbonitrile (119 mg, 0.500 mmol) and borane-THF (2 mL, 1M in THF, 2 eq) was heated at 65° C. for 2 hours. The reaction was cautiously quenched with ethanol (0.5 mL), sodium hydroxide (lmL, 5M aqueous) and stirred for two hours. It was then extracted with MTBE and evaporated. The residue was purified by HPLC to give cis 167 and trans 167.

1. customThe reaction was cautiously quenched with ethanol (0.5 mL), sodium hydroxide (lmL, 5M aqueous)
2. extractionIt was then extracted with MTBE
3. customevaporated
4. customThe residue was purified by HPLC
5. customto give cis 167 and trans 167