HCID 68750672, compound → HCID 68750602, compound

Participants

Reaction Steps

Tert-butyl 4-(1-(2-(benzyloxy)-2-oxoethyl)cyclopentylamino)-3-(biphenyl-4-ylmethyl)-4-oxobutanoate was dissolved in EtOAc (6 mL) and hydrogenated with 10% Pd/C at room temperature under hydrogen. After 2 hr, the reaction mixture was concentrated under reduced pressure. The obtained residue was dissolved in DCM, and to the mixture was added TFA. After stirred at room temperature for 1.5 hr, the reaction mixture was concentrated under reduced pressure. The obtained residue was purified by reverse phase HPLC [40 to 75% ACN-water (0.1% TFA) over 10 min by Sunfire C18 column] to give the title compound (23 mg). LCMS (condition B): 410.1 (M+1); retention time=0.99 min. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.38-1.61 (m, 6H), 1.95-2.05 (m, 2H), 2.10 (dd, J=16.4, 5.8 Hz, 1H), 2.41-2.49 (m, 1H), 2.57 (dd, J=12.9, 7.1 Hz, 1H), 2.73 (dd, J=35.4, 14.7 Hz, 2H), 2.82-2.99 (m, 2H), 7.29 (d, J=8.1 Hz, 2H), 7.34 (t, J=7.3 Hz, 1H), 7.45 (t, J=7.7 Hz, 2H), 7.56 (d, J=8.3 Hz, 2H), 7.63 (d, J=7.1 Hz, 3H), 11.97 (br. s., 2H).

Provenance & Evidence