Hydrochloric Acid → HCID 86665068, compound

Participants

Reaction Steps

A solution of (S)-benzyl 1-((S)-3-(biphenyl-4-yl)-2-(tert-butoxycarbonylamino)propanoyl)pyrrolidine-2-carboxylate (429 mg, 0.812 mmol) and HCl in 1,4-dioxane (2.03 ml, 8.12 mmol) was allowed to stir for 1 hour and concentrated under reduced pressure to give (S)-benzyl 1-((S)-2-amino-3-(biphenyl-4-yl)propanoyl)pyrrolidine-2-carboxylate hydrochloride (396 mg); Retention time=1.00 minutes (condition B); MS (m+1)=429.2.

Provenance & Evidence