反应详情

A solution of tert-butyl 2-cyano-3-(4-methoxyphenyl)propanoate (50 mg, 0.191 mmol) in EtOH (4 ml) was hydrogenated with Raney-Cobalt at 50° C. (30 atm) for 2 hours. The reaction mixture was concentrated under reduced pressure to give tert-butyl 3-amino-2-(4-methoxybenzyl)propanoate (50.1 mg); Retention time=1.24 minutes (condition A); MS (m+1)=266.3.

1. customfor 2 hours
2. concentrationThe reaction mixture was concentrated under reduced pressure