HCID 68751051, compound → HCID 68746979, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of (Z)-tert-butyl 2-cyano-3-(4-(pyridin-2-yl)phenyl)acrylate (340 mg, 1.110 mmol) and zinc (1089 mg, 16.65 mmol) in AcOH (6.5 ml) was stirred at 100° C. for 2 hours. The mixture was cooled to room temperature and filtered. To the filtrate was added EtOAc and water, and the mixture was basified by aq. NaOH. The combined organic layer was washed with brine and dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The obtained residue was purified by flash chromatography (silica gel, 15 to 30% EtOAc/Heptane) and gave the title compound: 150 mg (yield: 44%). LCMS (condition B): 309.2 (M+1); retention time=1.09 min.

Provenance & Evidence