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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 333338Generated: October 28, 2026

Trifluoroacetic acid → HCID 178511761, compound

https://huagongshe.com/reaction/333338

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
Reactant(S)-Tert-butyl 2-(3'-chlorobiphenyl-4-yl)-1-(1H-tetrazol-5-yl)ethylcarbamateHCID 178454141—
SolventDichloromethaneHCID 6344—
ProductHCID 178511761HCID 178511761—

Reaction Steps

To a solution of (S)-tert-butyl 2-(3′-chlorobiphenyl-4-yl)-1-(1H-tetrazol-5-yl)ethylcarbamate (250 mg, 0.625 mmol) in DCM (5 ml) at room temperature was added TFA (2 ml, 26.0 mmol), and the mixture was stirred at room temperature for 0.5 hour. The mixture was concentrated under reduced pressure and obtained the title compound. LCMS (condition A): 300.1 (M+1); retention time=1.20 min.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08877815B2
Source datasetuspto-grants-2014_11
ORD IDord-6dfb14583bc747ca8fac8a37b3df17bb
Source noteuspto-grants-2014_11