Hydrochloric Acid → HCID 178424507, compound

HRID 333342Notes

Reaction equation

HRID 333342 reaction equation
C(OC(=O)[NH:7][C@H:8]([C:23]1[NH:27][N:26]=[N:25][N:24]=1)[CH2:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([CH3:22])[CH:17]=2)=[CH:12][CH:11]=1)(C)(C)C.[ClH:29]>O1CCOCC1>[ClH:29].[CH3:22][C:18]1[CH:17]=[C:16]([C:13]2[CH:12]=[CH:11][C:10]([CH2:9][C@H:8]([NH2:7])[C:23]3[NH:27][N:26]=[N:25][N:24]=3)=[CH:15][CH:14]=2)[CH:21]=[CH:20][CH:19]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178424510[(S)-2-(3'-methyl-biphenyl-4-yl)-1-(1H-tetrazol-5-yl)-ethyl]-carbamic acid tert-butyl ester

Product 1

HCID 178424507HCID 178424507, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

[(S)-2-(3′-Methyl-biphenyl-4-yl)-1-(1H-tetrazol-5-yl)-ethyl]-carbamic acid tert-butyl ester (560 mg, 1.48 mmol) was treated with 4M HCl in dioxane (10 mL) at room temperature for 2 hours. The reaction mixture was concentrated in vacuo to give (S)-2-(3′-methyl-biphenyl-4-yl)-1-(1H-tetrazol-5-yl)-ethylamine hydrochloride; MS: m/z (MH+) 280; Retention time=1.14 min. (condition A).

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-db5ad15514b5499ca45e7bd5e7283735
Source dataset
uspto-grants-2014_11
Patent number
US08877815B2

Reaction notes

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