Methylamine → HCID 68205821, compound

Participants

Reaction Steps

3-chloro-N-phenylpyrazin-2-amine (4.5 g, 21.22 mmol) was stirred with methyl amine (20.59 g, 20.9 mmol, 33 wt % in THF) under reflux overnight. The solvent was evaporated and the residue was purified by column chromatography using 50% ethyl acetate and hexanes to give N2-methyl-N3-phenylpyrazine-2,3-diamine (2.4 g, 54.8%).

Provenance & Evidence