HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → 3-Iodo-N-methylpyridin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | 2-Fluoro-3-iodopyridine | HCID 7009501 | — |
| Product | 3-Iodo-N-methylpyridin-2-amine | HCID 14047146 | 95% |
Reaction Steps
A 1 L round bottom flask was charged with 2-fluoro-3-iodopyridine (27.0 g, 121 mmol) and 500 mL of 40% aqueous solution of methylamine. This was stirred at reflux for 4 h before being cooled to ambient temperature. The product was extracted with dichloromethane. Evaporation of the dichloromethane gave 3-iodo-N-methylpyridin-2-amine (26.8 g, 95% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08883322B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-a99fea72260e4f50968c688851281af9 |
| Source note | uspto-grants-2014_11 |