反应详情

Crude 4-isopropoxy-3-isothiocyanato-benzenesulfonamide (17.8 g, 65.2 mmol, example 2, step e) was treated with a 2 M solution of ammonia in MeOH (250 mL) and the resulting solution was stirred at room temperature for 18 h. The reaction mixture was then concentrated to about half the volume until a large amount of tan solid precipitated. The suspension was cooled to 0° C. for 30 minutes and was filtered. The solid was washed with methanol and ether to give the title compound as a cream colored solid.

1. concentrationThe reaction mixture was then concentrated to about half the volume until a large amount of tan solid
2. customprecipitated
3. temperatureThe suspension was cooled to 0° C. for 30 minutes
4. filtrationwas filtered
5. washThe solid was washed with methanol and ether