反应详情

2-(4-acetyl-phenylazo)-2-(3,3-dimethyl-3,4-dihydro-2H-isoquinoline-1-ylidene) acetamide (Asinex Corp., Russia) and sodium carbonate are added to acetonitrile, and an acetonitrile solution of methyl iodide is slowly dropped and refluxed. The refluxed product is cooled to room temperature and, then, the solvent is removed by reducing a pressure; the residue is dissolved in dichloromethane and washed with distilled water. Thereafter, the product is dried with anhydrous sodium sulfate and filtered and, then, the solvent is removed by reducing the pressure. The residue containing the reaction product is purified by column chromatography to obtain the title compound.

1. temperaturerefluxed
2. customthe solvent is removed
3. dissolutionthe residue is dissolved in dichloromethane
4. washwashed with distilled water
5. dry with materialThereafter, the product is dried with anhydrous sodium sulfate
6. filtrationfiltered
7. customthe solvent is removed
8. additionThe residue containing the reaction product
9. customis purified by column chromatography