反应详情

2-(4-acetyl-phenylazo)-2-(3,3-dimethyl-3,4-dihydro-2H-isoquinoline-1-ylidene)-acetamide (Asinex Corp., Russia) and dimethylaminopyridine are dissolved in pyridine on the ice bath, and acetic anhydride is added. After the reaction is stopped, the solvent after the reaction as described above is poured on ice water to extract the reaction product by adding dichloromethane. The reaction product is dried by using anhydrous sodium sulfate and filtered and, then, the solvent is removed by reducing the pressure. The residue containing the reaction product is purified by column chromatography to obtain the title compound.

1. additionis added
2. customthe solvent after the reaction
3. additionabove is poured on ice water
4. extractionto extract the reaction product
5. additionby adding dichloromethane
6. customThe reaction product is dried
7. filtrationfiltered
8. customthe solvent is removed
9. additionThe residue containing the reaction product
10. customis purified by column chromatography