HCID 53380668, compound → HCID 67404004, compound

Participants

Reaction Conditions

Reaction Steps

The compound 7-methoxy-3-(4-methoxyphenyl)isoquinoline-1(2H)-one (300 mg, 1 mmol), benzyltriethylammonium chloride (1.68 g, 7 mmol) and 37% hydrochloric acid (20 mL) are introduced into a sealed tube. The medium is heated for 20 hours at 140° C. then the mixture is evaporated to dryness under reduced pressure. After the addition of water (20 mL) to the residue obtained, a precipitate is formed. It is filtered and dried under in order to produce the expected 7-hydroxy-3-(4-hydroxyphenyl)isoquinoline-1(2H)-one 57 (200 mg, 74%) in the form of a brown solid.

Provenance & Evidence