反应详情

温度

120 °C

A mixture of 3-(2-methoxybenzamido)thiophene-2-carboxamide (1.4 g, 5.0 mmol), 6 N aqueous NaOH (8 mL), and EtOH (8 mL) was heated at 120° C. for 16 h. The reaction was cooled, diluted with water, and extracted with CH2Cl2. The combined extracts were washed with water, dried over Na2SO4, and concentrated under vacuum to give 2-(2-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one (0.80 g, 62% yield). LC/MS: m/z 259.3 (M+H)+ at 2.32 min (10%-99% CH3CN (0.035% TFA)/H2O (0.05% TFA)).

1. temperatureThe reaction was cooled
2. extractionextracted with CH2Cl2
3. washThe combined extracts were washed with water
4. dry with materialdried over Na2SO4
5. concentrationconcentrated under vacuum