Morpholine → HCID 135581741, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of N-(2-cyano-5-(4-fluorophenyl)thiophen-3-yl)-2-methoxybenzamide (0.10 g, 0.57 mmol) and morpholine (0.20 mL) was heated in a microwave oven at 200° C. for 5 min. The reaction was purified by preparative reverse phase HPLC using 10%-99% CH3CN (0.035% TFA)/H2O (0.05% TFA) to give 2-(6-(4-fluorophenyl)-4-morpholinothieno[3,2-d]pyrimidin-2-yl)phenol. LC/MS: m/z 408 (M+H)+ at 4.76 min (10%-99% CH3CN (0.035% TFA)/H2O (0.05% TFA)).

Provenance & Evidence