反应详情

2-Amino-6-hydroxybenzothiazole, 2-Bromo-4-nitroacetophenone and absolute Ethanol are added together and heated to reflux for approximately 24 hours. Tetrabutylammonium iodide is added and the reaction is refluxed an additional 12 hours. The resulting yellow suspension is cooled and the solids collected and washed with Ethanol and Diethyl ether. The solids are dried under vacuum to give Intermediate 2.

1. temperatureheated
2. temperatureto reflux for approximately 24 hours
3. temperaturethe reaction is refluxed an additional 12 hours
4. temperatureThe resulting yellow suspension is cooled
5. customthe solids collected
6. washwashed with Ethanol and Diethyl ether
7. customThe solids are dried under vacuum