Hydrochloric Acid → HCID 89586491, compound

Participants

Reaction Conditions

Reaction Steps

Under an argon atmosphere, to a solution of calcium chloride (268 mg) in ethanol (4 mL) were added THF (2.8 mL) and sodium tetrahydroborate (183 mg) and the mixture was stirred at 0° C. for 30 min. Then, a solution of methyl 3-imidazo[1,2-a]pyridin-2-ylpropanoate (395 mg) in THF (1.2 mL) was added dropwise, and the mixture was allowed to warm to room temperature and stirred for 18 hr. Under ice-cooling, to the reaction mixture was added 1N hydrochloric acid (4.84 mL), and the mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/methanol) to give the title compound (223 mg).

Provenance & Evidence