1-Bromo-2-Chloroethane → HCID 89586388, compound

Participants

Reaction Steps

Under an argon atmosphere, to a solution of 1H-imidazo[1,2-a]imidazole.hydrochloride (85 mg) in DMF (3 mL) was added 60% sodium hydride (52.1 mg), and the mixture was stirred under ice-cooling for 1 hr. Then, a solution of 1-bromo-2-chloroethane (170 mg) in DMF (0.5 mL) was added, and the mixture was stirred at room temperature for 18 hr. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/methanol) to give the title compound (38 mg).

Provenance & Evidence