HCID 66813086, compound → HCID 66813041, compound

Participants

Reaction Steps

2-(2-Chloro-4-methoxy-phenyl)-3-(2-methyl-pyridin-4-yl)-3-oxo-propionitrile (1.2 g, 4.0 mmol) was suspended in aqueous HBr (48%, 12 mL) and heated to reflux overnight. Upon cooling, the precipitated yellow solid was filtered and dried. The product (420 mg, 40%) was used in the next step without further purification. 1H NMR (300 MHz, DMSO-D6) 8.84 (1H, d), 8.09 (1H, s), 7.97 (1H, d), 7.19 (1H, d), 6.85 (1H, d), 6.73 (1H, dd), 4.49 (2H, s), 2.69 (3H, s); MS (m/e)=262.0 [MH+].

Provenance & Evidence