1-Bromo-3,6-dioxaheptane → HCID 25254297, compound

HRID 333780Notes

Reaction equation

HRID 333780 reaction equation
Br[CH2:2][CH2:3][O:4][CH2:5][CH2:6][O:7][CH3:8].[Cl:9][C:10]1[CH:11]=[C:12]([OH:31])[CH:13]=[CH:14][C:15]=1[CH:16]([CH3:30])[C:17]([OH:29])([C:22]1[CH:27]=[N:26][C:25]([CH3:28])=[CH:24][N:23]=1)[C:18]([F:21])([F:20])[F:19]>>[Cl:9][C:10]1[CH:11]=[C:12]([O:31][CH2:2][CH2:3][O:4][CH2:5][CH2:6][O:7][CH3:8])[CH:13]=[CH:14][C:15]=1[CH:16]([CH3:30])[C:17]([C:22]1[CH:27]=[N:26][C:25]([CH3:28])=[CH:24][N:23]=1)([OH:29])[C:18]([F:21])([F:19])[F:20]

Participants

3

Reactant 2

HCID 1235321-Bromo-3,6-dioxaheptaneHCID 574212313-Chloro-4-[3,3,3-trifluoro-2-hydroxy-1-methyl-2-(5-methyl-pyrazin-2-yl)-propyl]-phenol

Product 1

HCID 25254297HCID 25254297, compound

Procedure

The title compound was prepared in analogy to Example 74 from 1-bromo-2-(2-methoxyethoxy)ethane and 3-chloro-4-[3,3,3-trifluoro-2-hydroxy-1-methyl-2-(5-methyl-pyrazin-2-yl)-propyl]-phenol (Example 72). MS (m/e)=449.0 (MH+).

Sources & evidence

ORD record
ord-5b3809cf3f9943b3b195c942a97e52d1
Source dataset
uspto-grants-2014_11
Patent number
US08883786B2

Reaction notes

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