tert-Butyl bromoacetate → {3-Chloro-4-[3,3,3-trifluoro-2-hydroxy-1-methyl-2-(5-methyl-pyrazin-2-yl)-propyl]-phenoxy}-acetic acid tert-butyl ester
Reaction equation
Br[CH2:2][C:3]([O:5][C:6]([CH3:9])([CH3:8])[CH3:7])=[O:4].[Cl:10][C:11]1[CH:12]=[C:13]([OH:32])[CH:14]=[CH:15][C:16]=1[CH:17]([CH3:31])[C:18]([OH:30])([C:23]1[CH:28]=[N:27][C:26]([CH3:29])=[CH:25][N:24]=1)[C:19]([F:22])([F:21])[F:20]>>[C:6]([O:5][C:3](=[O:4])[CH2:2][O:32][C:13]1[CH:14]=[CH:15][C:16]([CH:17]([CH3:31])[C:18]([OH:30])([C:23]2[CH:28]=[N:27][C:26]([CH3:29])=[CH:25][N:24]=2)[C:19]([F:20])([F:21])[F:22])=[C:11]([Cl:10])[CH:12]=1)([CH3:9])([CH3:8])[CH3:7]Participants
3
Procedure
The title compound was prepared in analogy to Example 74 from tert-butyl bromoacetate and 3-chloro-4-[3,3,3-trifluoro-2-hydroxy-1-methyl-2-(5-methyl-pyrazin-2-yl)-propyl]-phenol (Example 72). MS (m/e)=461.1 (MH+).
Sources & evidence
- ORD record
- ord-e30dd0d6b712456ab92ed4d5e9ef4079
- Source dataset
- uspto-grants-2014_11
- Patent number
- US08883786B2
Reaction notes
Loading…