tert-Butyl N-(2-bromoethyl)carbamate → HCID 57421234, compound

HRID 333783Notes

Reaction equation

HRID 333783 reaction equation
[C:1]([NH:8][CH2:9][CH2:10]Br)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[Cl:12][C:13]1[CH:14]=[C:15]([OH:34])[CH:16]=[CH:17][C:18]=1[CH:19]([CH3:33])[C:20]([OH:32])([C:25]1[CH:30]=[N:29][C:28]([CH3:31])=[CH:27][N:26]=1)[C:21]([F:24])([F:23])[F:22]>>[C:4]([O:3][C:1](=[O:2])[NH:8][CH2:9][CH2:10][O:34][C:15]1[CH:16]=[CH:17][C:18]([CH:19]([CH3:33])[C:20]([OH:32])([C:25]2[CH:30]=[N:29][C:28]([CH3:31])=[CH:27][N:26]=2)[C:21]([F:22])([F:23])[F:24])=[C:13]([Cl:12])[CH:14]=1)([CH3:7])([CH3:6])[CH3:5]

Participants

3

Reactant 2

HCID 4103526tert-Butyl N-(2-bromoethyl)carbamateHCID 574212313-Chloro-4-[3,3,3-trifluoro-2-hydroxy-1-methyl-2-(5-methyl-pyrazin-2-yl)-propyl]-phenol

Product 1

HCID 57421234HCID 57421234, compound

Procedure

The title compound was prepared in analogy to Example 74 from 2-(BOC-amino)ethyl bromide and 3-chloro-4-[3,3,3-trifluoro-2-hydroxy-1-methyl-2-(5-methyl-pyrazin-2-yl)-propyl]-phenol (Example 72). MS (m/e)=489.9 (MH+).

Sources & evidence

ORD record
ord-8d6d9391cf184f6792141cef6b0e29a4
Source dataset
uspto-grants-2014_11
Patent number
US08883786B2

Reaction notes

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