2-Bromo-1,1-difluoroethane → HCID 57474047, compound

HRID 333784Notes

Reaction equation

HRID 333784 reaction equation
Br[CH2:2][CH:3]([F:5])[F:4].[Cl:6][C:7]1[CH:8]=[C:9]([OH:28])[CH:10]=[CH:11][C:12]=1[CH:13]([CH3:27])[C:14]([OH:26])([C:19]1[CH:24]=[N:23][C:22]([CH3:25])=[CH:21][N:20]=1)[C:15]([F:18])([F:17])[F:16]>>[Cl:6][C:7]1[CH:8]=[C:9]([O:28][CH2:2][CH:3]([F:5])[F:4])[CH:10]=[CH:11][C:12]=1[CH:13]([CH3:27])[C:14]([C:19]1[CH:24]=[N:23][C:22]([CH3:25])=[CH:21][N:20]=1)([OH:26])[C:15]([F:16])([F:18])[F:17]

Participants

3

Reactant 2

HCID 1361862-Bromo-1,1-difluoroethaneHCID 574212313-Chloro-4-[3,3,3-trifluoro-2-hydroxy-1-methyl-2-(5-methyl-pyrazin-2-yl)-propyl]-phenol

Product 1

HCID 57474047HCID 57474047, compound

Procedure

The title compound was prepared in analogy to Example 74 from 2-bromo-1,1-difluoroethane and 3-chloro-4-[3,3,3-trifluoro-2-hydroxy-1-methyl-2-(5-methyl-pyrazin-2-yl)-propyl]-phenol (Example 72). MS (m/e)=411.0 (MH+).

Sources & evidence

ORD record
ord-e0bf2376034648819e2a71c5e307684c
Source dataset
uspto-grants-2014_11
Patent number
US08883786B2

Reaction notes

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