HCID 18411630, compound → HCID 57474050, compound

HRID 333791Notes

Reaction equation

HRID 333791 reaction equation
Cl[CH2:2][C:3]1[S:7][N:6]=[C:5]([CH3:8])[N:4]=1.[Cl:9][C:10]1[CH:11]=[C:12]([OH:31])[CH:13]=[CH:14][C:15]=1[CH:16]([CH3:30])[C:17]([OH:29])([C:22]1[CH:27]=[N:26][C:25]([CH3:28])=[CH:24][N:23]=1)[C:18]([F:21])([F:20])[F:19]>>[Cl:9][C:10]1[CH:11]=[C:12]([O:31][CH2:2][C:3]2[S:7][N:6]=[C:5]([CH3:8])[N:4]=2)[CH:13]=[CH:14][C:15]=1[CH:16]([CH3:30])[C:17]([C:22]1[CH:27]=[N:26][C:25]([CH3:28])=[CH:24][N:23]=1)([OH:29])[C:18]([F:19])([F:21])[F:20]

Participants

3

Reactant 2

HCID 18411630HCID 18411630, compoundHCID 574212313-Chloro-4-[3,3,3-trifluoro-2-hydroxy-1-methyl-2-(5-methyl-pyrazin-2-yl)-propyl]-phenol

Product 1

HCID 57474050HCID 57474050, compound

Procedure

The title compound was prepared in analogy to Example 74 from 5-chloromethyl-3-methyl-[1,2,4]thiadiazole [163009-79-8] and 3-chloro-4-[3,3,3-trifluoro-2-hydroxy-1-methyl-2-(5-methyl-pyrazin-2-yl)-propyl]-phenol (Example 72). MS (m/e)=459.5 (MH+).

Sources & evidence

ORD record
ord-41f6f53aa129408083c36bad90a5348b
Source dataset
uspto-grants-2014_11
Patent number
US08883786B2

Reaction notes

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