Bromoacetonitrile → HCID 57421257, compound

HRID 333818Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH:9]([CH3:23])[C:10]([C:16]1[CH:21]=[CH:20][NH:19][C:18](=[O:22])[CH:17]=1)([OH:15])[C:11]([F:14])([F:13])[F:12].Br[CH2:25][C:26]#[N:27]>>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH:9]([CH3:23])[C:10]([C:16]1[CH:21]=[CH:20][N:19]=[C:18]([O:22][CH2:25][C:26]#[N:27])[CH:17]=1)([OH:15])[C:11]([F:14])([F:13])[F:12]

Participants

Reactant 2

HCID 11534Bromoacetonitrile

HCID 57421256HCID 57421256, compound

Product 1

HCID 57421257HCID 57421257, compound

Procedure

The title compound was prepared in analogy to Example 120 from 4-[2-(2,4-Dichloro-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-1H-pyridin-2-one (Example 119, 100 mg) and bromo-acetonitrile (0.022 mL). MS (m/e)=405.2 (MH+).

Sources & evidence

ORD record: ord-56bd4b1f7f27497bb2fb0ec59c2cdc52
Source dataset: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08883786B2

Reaction notes

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