Boron tribromide → HCID 66813165, compound

Participants

Reaction Steps

4′-[2-(2-Chloro-4-methoxy-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-carboxylic acid ethyl ester (Example 154, 57 mg) in dichloromethane (0.5 mL) under argon, was treated with 1M-BBr3 in dichloromethane (0.341 mL). The solution was poured into ice-water/NaHCO3, extracted twice with dichloromethane. The combined organic phases were washed with brine, dried over MgSO4 and evaporated in vacuo. The residue was purified by flash chromatography (4 g silica gel, heptane/ethyl acetate 2/1) to give the title compound as amorphous colorless solid (41 mg). MS (m/e)=487.2 (MH+).

Provenance & Evidence